Researchers discovered that the brain can significantly influence the immune system, particularly its inflammatory responses. The study utilized mice to show that the brain can detect and adjust levels of inflammation via a specific brain circuit involving the caudal nucleus of the solitary tract.
Researchers discovered a promising treatment for multiple sclerosis (MS) using a novel protein function inhibitor, ESI1, which effectively regenerates myelin—a crucial protective coating on nerve cells that deteriorates in MS. The study showcases that ESI1 reactivates the brain’s capacity to produce myelin, overcoming traditional barriers that have hindered myelin regeneration.
Researchers uncovered how the influenza virus may infiltrate the brain, leading to a serious condition known as influenza-associated encephalopathy (IAE). The study identifies endothelial cells, which form the blood-brain barrier, as the primary entry points for the virus.
Researchers introduced a new mRNA cancer vaccine that rapidly activates the immune system against glioblastoma, the deadliest form of brain tumor. This new vaccine technology, which mimics the structure of COVID-19 vaccines but incorporates personalized tumor cells and a complex cluster delivery system, has shown promising results in preclinical models and an initial human trial […]
Remembering past anger can significantly impair blood vessel function, crucial for maintaining healthy blood flow. The study involved 280 adults who underwent emotional tasks that induced feelings of anger, anxiety, or sadness, and their vascular responses were measured.
Researchers have pioneered a method to enhance the generation of dopaminergic neurons, crucial for Parkinson’s disease treatment, by targeting specific receptors within the Wnt signaling pathway. Using synthetic antibodies, the team successfully directed stem cell differentiation in the midbrain to produce these key neurons, which are instrumental in brain health and depleted in Parkinson’s patients.
A new study uncovered how diets high in saturated fats contribute to the development of Alzheimer’s disease by affecting crucial molecular markers in the brain and blood. The research utilized mouse models to investigate the impact of such diets on the expression of miRNAs related to insulin regulation, revealing significant metabolic deterioration and brain inflammation.
Researchers developed innovative, flexible devices that can gently wrap around nerve fibers, potentially transforming the diagnosis and treatment of neurological disorders. These tiny, flexible “nerve cuffs” employ soft robotics and flexible electronics to interface with peripheral nerves without causing damage.
Researchers made a significant breakthrough in ALS treatment using a new gene therapy, marking a notable slow in disease progression for a patient with an aggressive form of ALS. The patient, treated since early 2020, has maintained much of their physical and social abilities, exceeding typical life expectancy and functionality projections for their condition.
A new study demonstrates how spinal cord injuries can lead to significant metabolic disruptions, including the onset of conditions such as diabetes and heart disease. The study found that abnormal neuronal activities post-injury lead to excessive breakdown of triglycerides in fat tissue, releasing harmful compounds into organs like the liver.